For women, things are a bit different. They do not need SERMs because they produce so little testosterone naturally that suppression isn’t as detrimental. However, Anavar and Winstrol act much like testosterone in the female body, and using the combination over the course of four to six weeks can create a hormonal imbalance. Women who simply come off steroids cold turkey, even after a few weeks, may notice undesirable effects like fatigue and irritability. To avoid this, simply reducing dose toward the end of the cycle can help tremendously.