Steroid and antibiotic eye drops - hydrocortisone/neomycin/polymixin B; loteprednol/tobramycin; prednisolone/gentamycin; prednisolone/sulfacetamide; hydrocortisone /neomycin/bacitracin/ polymyxin B (Blephamide, Catapred [discontinued], Isopto, Pred-G, Poly-Pred [discontinued], Tobradex, Zylet and many other brands) are steroid and antibiotic eye drops prescribed to prevent or treat eye infections that are associated with inflammation. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to using these medications.
Nursing Mothers. Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Because many drugs are excreted in human milk, caution should be exercised when TOBRADEX® (tobramycin and dexamethasone opthalmic ointment) (tobramycin and dexamethasone ophthalmic ointment) is administered to a nursing woman.
Prolonged use of steroids may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation. Intraocular pressure should be routinely monitored even though it may be difficult in pediatric patients and uncooperative patients. Prolonged use may suppress the host response and thus increase the hazard of secondary ocular infections. In those diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids. In acute purulent conditions of the eye, ste roids may mask infection or enhance existing infection.