Researchers also looked at how much patients were bothered by a combination of MS symptoms and AEs before, during, and after treatment. What they found was that the combined effect of symptoms and side effects was not substantially different between baseline and one week after treatment. This suggests that one week after treatment, the benefit gained from a decrease in MS symptoms was neutralized somewhat by the increased burden of adverse events related to treatment. Interestingly, the combined burden was the lowest on Day Two of IVMP treatment.
Loratadine /pseudoephedrine is a combination of two drugs , an antihistamine (loratadine) and a decongestant (pseudoephedrine). Loratadine is a long-acting antihistamine that blocks the actions of histamine that causes some of the symptoms of allergic reactions. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that are associated with allergy symptoms . Loratadine blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine. Unlike some antihistamines , loratadine does not enter the brain from the blood and, therefore, does not cause drowsiness when taken at recommended doses. It is one of a few antihistamines that do not cause sedation. Pseudoephedrine decongests tissues by causing blood vessels to constrict.
Lots of unsubstantiated alternative eczema therapies are promoted in the press. Be wary of these claims. Miraculous natural cures for eczema often contain crushed cortisone tablets. Evening Primrose oil (or gamolenic acid), flaxseed & omega 3 oils offer no real additional benefit to eczema. Chinese herbal tea extracts have been evaluated but taste unpleasant and may even cause liver toxicity. Recalcitrant eczema on the face may respond to non-steroidal immune-modulator preparations such as Tacrolimus (Protopic) and Pimecrolimus (Elidel) however skin redness may be a temporary side effect. Ultra-violet light therapy treatment has been helpful so get out into the sunshine! There is growing proof that lactobacillus GG probiotics (Reuterina) supplemented in pregnancy, breastfeeding and early in life may reduce eczema in babies by altering their gut immune reactivity.