Prophylactic steroids for pediatric open heart surgery

Hepatotoxicity, Including VOD: Hepatotoxicity, including fatal and life-threatening VOD, occurred in patients who received BESPONSA. The risk of VOD was greater in patients who underwent HSCT after BESPONSA treatment. The use of HSCT conditioning regimens containing 2 alkylating agents and last total bilirubin ≥ the upper limit of normal (ULN) before HSCT were significantly associated with an increased risk of VOD. Other risk factors for VOD in patients treated with BESPONSA included ongoing or prior liver disease, prior HSCT, increased age, later salvage lines, and a greater number of BESPONSA treatment cycles. Grade 3/4 increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin have occurred.

HIV - Antiretroviral medications may be approved on an individual basis and should be prescribed in compliance with the 1996 DHHS Panel recommendations regarding the Clinical Practices for the Treatment of HIV. Approved medications include: Epivir (Lamivudine)                               MORE

  1. Male patients with carcinoma of the breast , or with known or suspected carcinoma of the prostate .
  2. Carcinoma of the breast in females with hypercalcemia ; androgenic anabolic steroids may stimulate osteolytic resorption of bone .
  3. Nephrosis or the nephrotic phase of nephritis .
  4. WINSTROL (anabolic steroids) can cause fetal harm when administered to a pregnant woman.
WINSTROL (anabolic steroids) is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy , or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus .

Prophylactic steroids for pediatric open heart surgery

prophylactic steroids for pediatric open heart surgery

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