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In clinical studies, cyproterone was found to be far less potent and effective as an antiandrogen relative to CPA, likely in significant part due to its lack of concomitant antigonadotropic action. [3] Cyproterone was studied as a treatment for precocious puberty by Bierich (1970, 1971), but no significant improvement was observed. [18] In men, 100 mg/day cyproterone proved to be rather ineffective in treating acne , which was hypothesized to be related to its progonadotropic effects in males and counteraction of its antiandrogen activity. [3] [19] In women however, in whom the drug has no progonadotropic activity, 100–200 mg/day oral cyproterone was effective in reducing sebum production in all patients as early as 2–4 weeks following the start of treatment. [3] In contrast, topical cyproterone was far less effective and barely outperformed placebo . [3] In addition, another study showed disappointing results with 100 mg/day cyproterone for reducing sebum production in women with hyperandrogenism . [3] Similarly, the drug showed disappointing results in the treatment of hirsutism , with a distinct hair reduction occurring in only a limited percentage of cases. [3] In the same study, the reduction of acne was better, but clearly inferior to that produced by CPA, and only the improvement in seborrhea was regarded as satisfactory. [3] The addition of an oral contraceptive to cyproterone resulted in a somewhat better improvement in acne and seborrhea relative to cyproterone alone. [3] According to Jacobs (1979), “[cyproterone] proved to be without clinical value for reasons that cannot be discussed here.” [20] In any case, cyproterone has been well-tolerated by patients in dosages of up to 300 mg/day. [3]

Oral exemestane 25 mg/day for 2–3 years of adjuvant therapy was generally more effective than 5 years of continuous adjuvant tamoxifen in the treatment of postmenopausal women with early-stage estrogen receptor-positive/unknown receptor status breast in a large well-designed [ citation needed ] trial. Preliminary data from the open-label TEAM trial comparing exemestane with tamoxifen indicated in 2009 that exemestane 25 mg/day is also effective in the primary adjuvant treatment of early-stage breast cancer in postmenopausal women. [17]

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