Neurosteroid pregnenolone

I found an old interview with you regarding your book on Pregnenolone. Checking out your website, I notice you have warnings about dosage. Have you changed your mind? Do you think it has too many risks? For me, Pregnenolone feels like a miracle. I have suffered with vestibulitis for ten years .. all the years that my hormones have been plummeting. I am 47. I have always been fit. I believe my hormone issues are from having been on the pill for years to control endometriosis (I quit the pill ten years ago also, but I had started having symptoms before that). Anyway, I have tried every Rx, diet, PT, herb, acupuncture, etc. Bio-identical hormones gave some help. Recently I tried pregnenolone and my pain immediately decreased by 75% and I had a sudden urge to paint, which I have not done in 15 years! Do you feel it is risky for someone like me, who produces very little of any key hormones, to take pregnenolone 10mg/day? Or was that warning more for folks who still produce normal levels? I hope you'll write back. I am AMAZED to find an MD who knows what this is and what it does.
   A. I think one should be cautious taking 10 mg a day for prolonged periods. I good idea is to adjust the dosage periodically to find the lowest amount that works and to also take a couple of days off each week if possible.

Acetyl L-Carnitine ((R)-3-Acetyloxy-4-trimethylammonio-butanoate) and commonly abbreviated as ALCAR) is an acetylated form of the compound L-Carnitine. Unlike Carnitine, Acetyl L-Carnitine is able to cross the blood-brain barrier. Once it reaches the brain, it is converted into Acetyl-COA, which binds with choline already present to become acetylcholine. Acetylcholine is a neurotransmitter closely tied to many important cognitive functions, such as the formation of memory, reasoning skills, processing of perceptual data, and the ability of neural structures to grow.

Benzodiazepines may influence neurosteroid metabolism by virtue of their actions on translocator protein (TSPO; "peripheral benzodiazepine receptor"). [59] The pharmacological actions of benzodiazepines at the GABA A receptor are similar to those of neurosteroids . Factors which affect the ability of individual benzodiazepines to alter neurosteroid levels may depend upon whether the individual benzodiazepine drug interacts with TSPO. Some benzodiazepines may also inhibit neurosteroidogenic enzymes reducing neurosteroid synthesis. [60]

Lipoic Acid is a highly potent antioxidant that counteracts reactive free radicals in the mitochondria, the power plants of cells where energy for all cellular activities is generated. Some scientists believe that mitochondrial free radicals play an important role in human aging, and have theorized that extra amounts of free-radical inhibiting compounds such as lipoic acid may be able to help slow aging. Lipoic acid is also effective in recycling other antioxidants such as Vitamin E back into their original form after they detoxify free radicals. There also is evidence that lipoic acid can reduce glycation damage due to excess glucose in the blood, which may be involved in aging. Lipoic acid consists of two different forms (isomers) that have vastly different properties. The "R" form is the biologically active component (native to the body) that is responsible for lipoic acid's phenomenal antioxidant effect.

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Neurosteroid pregnenolone

neurosteroid pregnenolone

Lipoic Acid is a highly potent antioxidant that counteracts reactive free radicals in the mitochondria, the power plants of cells where energy for all cellular activities is generated. Some scientists believe that mitochondrial free radicals play an important role in human aging, and have theorized that extra amounts of free-radical inhibiting compounds such as lipoic acid may be able to help slow aging. Lipoic acid is also effective in recycling other antioxidants such as Vitamin E back into their original form after they detoxify free radicals. There also is evidence that lipoic acid can reduce glycation damage due to excess glucose in the blood, which may be involved in aging. Lipoic acid consists of two different forms (isomers) that have vastly different properties. The "R" form is the biologically active component (native to the body) that is responsible for lipoic acid's phenomenal antioxidant effect.

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