Neurosteroid effects in the central nervous system the role of the gabaa receptor

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility, reproductive function, and sensorimotor control have shed new light on this complex field and inspired exciting developments. Neurosteroid Effects in the Central Nervous System: The Role of the GABA A Receptor presents a complete overview of the effects of neuroactive steroids in the brain, describes new methods for investigating these effects, and features the latest theories on steroid action in the central nervous system, with emphasis on the GABA A receptor. The text discusses techniques for receptor localization and quantification, recombinant expression systems to identify steroid-responsive receptor isoforms, the use of transgenic/antisense strategies to determine steroid effects on neuronal circuits and behavior, and techniques to examine the cellular effects of steroid action in the brain. The material covers the range of steroid action on such end points as mood, cognition, epilepsy, neuroprotection, and learning/plasticity, and it describes methods using molecular, electrophysiological, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects. This timely compilation provides important insight into the possibilities for steroid effects on the central nervous system. It will appeal to the clinical, behavioral, and molecular interests of research scientists, clinicians, and students interested in broadening their knowledge about neurosteroid effects with relevance to premenstrual syndrome and post-partum changes.

I found an old interview with you regarding your book on Pregnenolone. Checking out your website, I notice you have warnings about dosage. Have you changed your mind? Do you think it has too many risks? For me, Pregnenolone feels like a miracle. I have suffered with vestibulitis for ten years .. all the years that my hormones have been plummeting. I am 47. I have always been fit. I believe my hormone issues are from having been on the pill for years to control endometriosis (I quit the pill ten years ago also, but I had started having symptoms before that). Anyway, I have tried every Rx, diet, PT, herb, acupuncture, etc. Bio-identical hormones gave some help. Recently I tried pregnenolone and my pain immediately decreased by 75% and I had a sudden urge to paint, which I have not done in 15 years! Do you feel it is risky for someone like me, who produces very little of any key hormones, to take pregnenolone 10mg/day? Or was that warning more for folks who still produce normal levels? I hope you'll write back. I am AMAZED to find an MD who knows what this is and what it does.
   A. I think one should be cautious taking 10 mg a day for prolonged periods. I good idea is to adjust the dosage periodically to find the lowest amount that works and to also take a couple of days off each week if possible.

Neurosteroid effects in the central nervous system the role of the gabaa receptor

neurosteroid effects in the central nervous system the role of the gabaa receptor

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