Mechanism of action of corticosteroids in allergic

Urinary retention in patients with bladder outlet obstruction (BOO) and in patients taking antimuscarinic medications for the treatment of OAB has been reported in postmarketing experience in patients taking mirabegron. A controlled clinical safety study in patients with BOO did not demonstrate increased urinary retention in Myrbetriq patients; however, Myrbetriq should be administered with caution to patients with clinically significant BOO. Myrbetriq should also be administered with caution to patients taking antimuscarinic medications for the treatment of OAB.

A microdialysis study in rats concluded that modafinil inhibits striatal and pallidal GABA release 14 . Moreover, modafinil dose-dependently increases extracellular glutamate and enhances excitatory glutamatergic neurotransmission in the ventromedial (VMT), ventrolateral (VLT), thalamus and hippocampal regions of wild-type rats 15 . Hence, modafinil’s tendency to increase the glutamate/GABA ratio may account for some of its wake-promoting effects, although dopamine agonists and dopamine itself both elicit glutamate release in the hippocampus 16 , raising the possibility that increases in extracellular glutamate may arise secondarily from modafinil’s action on DA.

Mechanism of action of corticosteroids in allergic

mechanism of action of corticosteroids in allergic

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