AB - Objective: To review published literature regarding the use of intratympanic steroids in the treatment of Ménière's disease and sudden sensorineural hearing loss and to make recommendations regarding their use based on the literature review. Data Sources: Literature review from 1996 to 2003, PubMed, Medline Plus, and Web of Science. Study Selection: Retrospective case series and uncontrolled prospective cohort studies were the only types of studies available for review. Conclusion: On the basis of the available literature, a weak recommendation is made to use intratympanic steroid treatment of sudden hearing loss if oral steroid therapy fails or is contraindicated. The available studies regarding intratympanic steroid treatment of Ménière's disease and tinnitus are inadequate to answer the question of the efficacy of this treatment for these conditions. Higher quality studies are needed.
Some reports maintain that a cold or other upper respiratory illness preceded the onset of SSNHL in as many as 40 percent of cases. Unfortunately, these reports lack corresponding data on the comparative frequency of upper respiratory illness in a matched control population. What about the evidence of blood examinations? In response to a virus, the immune system produces a temporary increase in the level of antibodies against the speciﬁc virus, and many case reports on patients with SSNHL show that they experience a brief, sharp rise in antibody levels against common viruses such as herpes, ﬂu, mumps, or rubella.