Canker sores are a common complaint, and are small ulcers on the inside of the mouth. Canker sores aren't contagious (as opposed to cold sores), and typically last for 10-14 days usually healing without scarring. A variety of things cause canker sores, for example, medications (aspirin, beta blockers, NSAIDs, high blood pressure medication, and antibiotics); injury to the mouth from dental work, braces, or sports accidents; acidic foods; allergies; and diseases or conditions like celiac disease, Crohn's disease, and lupus.
Bicalutamide monotherapy has been associated with abnormal liver function tests such as elevated liver enzymes in % of men relative to % for standard care.   Hepatic changes such as marked increases in liver enzymes or hepatitis that necessitated discontinuation of bicalutamide have occurred in approximately to 1% of men in clinical trials.   Monitoring of liver function during treatment is recommended, particularly in the first few months.   In men of advanced age with prostate cancer, bicalutamide monotherapy has been associated with an increase in non-prostate cancer mortality , in part due to an increase in the rate of heart failure.   These mortality-related effects are thought to be a consequence of androgen deprivation, rather than a specific drug-related toxicity of bicalutamide. 
An important group of hormones essential for normal women's maturation and the healthy functioning of reproductive and other tissues. During the reproductive years in women estrogens are primarily made in the ovaries. Estrogen is also normally made in children, men and menopausal women by conversion of androgens in fat and muscle tissues. There are three kinds of estrogens. Estradiol is the ovarian hormone of the premenopausal years, estrone is the hormone of the menopausal years and estriol, a weak estrogen is present in high levels during pregnancy. High levels are associated with nausea, breast tenderness, insulin resistance and fluid retention. OR the name for a family of hormones including estradiol, estrone and estriol.