It is worth noting that girls have a 4-8 times higher risk of UTI than boys.[94,95] The reason circumcision for little girls is not even considered as an option, is that no one has performed any studies to evaluate whether removing parts of their genitals might lessen their UTI risk. It is hypothetically possible, for example, that measures such as removing the labia minora would work in a similar way as removal of the male foreskin to lower UTI risk. However, such studies would be considered unethical, as would the treatment. Little girls with problems predisposing them to UTIs are typically treated with good toileting habits, preventive substances such as cranberry and low-dose daily antibiotics, therapeutic courses of antibiotics, observation, and surgery to correct anatomic abnormalities when it is believed that they will not improve with age. These treatments are also available and effective for little boys.