Corticosteroidi nasali

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

Steroid nasal sprays are medicines that are sprayed into the nose, to prevent and treat allergy symptoms of the nose such as stuffy or runny nose, itching, and sneezing. These usually occur with hay fever  (also called  allergic rhinitis ). Steroid nasal sprays are also used to treat certain growths in the nose called nasal polyps . They work by reducing swelling (inflammation) and mucus in the nose. Because the medicine mainly works in your nostrils, it has very little effect anywhere else in your body. People with hay fever only need to use them for a few months of the year, during the hay fever season, but others may need to use them long-term.

Corticosteroidi nasali

corticosteroidi nasali

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