Low levels of serotonin , a neurotransmitter in the brain, have been linked to depression . High levels of estrogen, as in first-generation COCPs, and progestin, as in some progestin-only contraceptives, have been shown to lower the brain serotonin levels by increasing the concentration of a brain enzyme that reduces serotonin. This observation, along with some small research studies  have inspired speculation that the pill causes depression. In 2016, a large Danish study of one million women showed that use of COCPs, especially among adolescents, was associated with a statistically significantly increased risk of subsequent depression, although the sizes of the effects are small (for example, % of the women who took any form of oral birth control were prescribed anti-depressants for the first time, compared to % of women in the control group). 
A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps ; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs. Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, CELEBREX is contraindicated in patients with this form of aspirin sensitivity [see CONTRAINDICATIONS ]. When CELEBREX is used in patients with preexisting asthma (without known aspirin sensitivity), monitor patients for changes in the signs and symptoms of asthma.
I’ve been fighting shingles now for 6 weeks and I’m still suffering from pain where the shingles blisters were located. I started 15 billion probiotics midway thru this and was feeling better. I was taking 5 billion 3 times a day. A friend coaxed me to bump it up to 20 billion. So I did this and by the 3rd day I had a rash all over my head. I’ve since stopped and the rash has gone away. I really want to go back on it, but now I’m stuck with 20 billion capsules. Any ideas on breaking these capsules in half to take half in the morning then again at night? Or should I wait til after this shingle pain goes away? I’m sure I’m in toxic overload with having fibromyalgia and type 2 diabetes. What would u suggest I do? Thank you.