Antenatal steroids guidelines rcog

In a multicentre RCT with 651 infants, Kendig et al [51] showed that there was no clinically significant difference in outcome between immediate administration of prophylactic surfactant and administration at 10 min after birth after a brief period of stabilization (evidence level 1b). However, giving the surfactant as soon as possible once stabilization has occurred seems to be important. The open study of infants at high risk of or with respiratory insufficiency – the role of surfactant (OSIRIS) [52] demonstrated that the combined incidence of death or BPD was reduced by about 11% when surfactant was given at a mean postnatal age of 2 h rather than 3 h (RR=, 95% CI to , evidence level 1b), showing that even fairly short delays in therapy worsen outcomes (evidence level 1b).

Antenatal steroids guidelines rcog

antenatal steroids guidelines rcog

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