Our goals vary depending on our pursuit, depending on our need but generally speaking the same rules apply to all if we are to maximize activity and reach the productive end we truly desire. For the individual who supplements with anabolic androgenic steroids for therapeutic measures, most commonly being that of low testosterone treatment, as testosterone is needed androgen replacement is really all they will be concerned with; after all, if you’re testosterone deficient the only thing that will cure it is androgen replacement. It is the performance enhancer that will truly find understanding here to be a little more worthwhile as quality stacks and cycles will generally include steroids of both anabolic and androgenic nature and activity.
As the use of anabolic androgenic steroids will suppress natural testosterone production, with total suppression varying from steroid to steroid, in most cases the primary androgen testosterone is needed in exogenous fashion in order to maintain adequate levels in the body while the cycle is in play. For many this will be the only androgen they will need and anything else they add may be of a strict anabolic capacity; this does not mean you must add anything, some will be fine even more than fine with only testosterone; after all, it is not only highly anabolic and androgenic in nature but equal in both in-terms of makeup and action and extremely well-tolerated by most healthy adult men. For others , especially those who are really looking to grow and this is found in many bodybuilding and hardcore gym circles, multiple androgenic items may be coupled together in the same cycle with an additional possible strong anabolic in nature steroid. Prime examples of such stacks might be Testosterone/Trenbolone/ Anadrol ; with this stack you have two steroids of powerful anabolic and androgenic power and a third steroid in Anadrol, while possessing decent androgenic activity highly anabolic in nature.
The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that AAS are not euphorigenic, meaning they do not trigger rapid increases in the neurotransmitter dopamine , which is responsible for the “high” that often drives substance abuse behaviors. However, long-term use of AAS can eventually have an impact on some of the same brain pathways and chemicals—such as dopamine, serotonin, and opioid systems—that are affected by other drugs of abuse. Considering the combined effect of their complex direct and indirect actions, it is not surprising that AAS can affect mood and behavior in significant ways.